Формат:
ePUB
Издател | Фондация Буквите |
Година на издаване | 2023 |
Език | английски |
Формат | ePUB |
ISBN | 9786191545506 |
Баркод | 9786191545506 |
Категории | Учебна литература, Е-книги |
L-type voltage-dependent calcium channels play an important role in memory formation and gene expression in the hippocampus. That is why we investigated their contribution and more specifically of CaV1.2 channel to neuronal excitability.
We evaluated and compared inward calcium currents, single action potentials and action potential series in presence and absence of L-type voltage-dependent calcium channels using primary culture of neonatal rat hippocampal cells.
Channel activity was regulated by use of dihydropyridine L-type calcium channel blocker nimodipine, and by gene silencing of the gene for CaV1.2 channel by siRNA. Currents and action potentials were recorded in whole-cell patch clamp configuration.
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